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收稿日期：2018-06-15作者简介： 黄楚燕（1982-），女，主管中药师；E-mail：1061850484@qq.com自拟加味瓜蒌薤白半夏汤对痰热蕴肺型慢性阻塞性肺疾病急性加重期患者炎症因子及凝血功能的影响黄楚燕1 ，梁宏宇2（1. 广州中医药大学第一附属医院药学部门诊中药房，广东广州 510405；2. 广东省第二中医院心脑血管二区，广东广州 510095）摘要：【目的】 观察自拟加味瓜蒌薤白半夏汤对痰热蕴肺型慢性阻塞性肺疾。虺坡璺危┘毙约又仄诨颊哐字⒁蜃蛹澳δ艿挠跋。【方法】 将132例痰热蕴肺型慢阻肺急性加重期患者随机分为试验组和对照组，每组各66例。对照组给予常规西药治疗，试验组在对照组基础上加用加味瓜蒌薤白半夏汤治疗，疗程均为2周。观察2组患者治疗前后肺功能指标、炎症因子、凝血功能指标的变化情况，并评价 2组临床疗效。【结果】（1）治疗 2周后，试验组总有效率为 74.24%，对照组为45.45%，试验组疗效明显优于对照组（P＜0.01）。（2）治疗后，2组患者的肺功能指标、炎症因子、凝血功能指标均较治疗前明显改善（P＜0.01），且除凝血酶时间（TT）外，试验组对各项肺功能指标、炎症因子、凝血功能指标的改善作用均优于对照组，差异均有统计学意义（P＜0.01）。【结论】 自拟加味瓜蒌薤白半夏汤能有效提高痰热蕴肺型慢阻肺急性加重期患者临床疗效，降低患者炎症因子水平，改善患者肺功能和凝血功能。关键词：瓜蒌薤白半夏汤；痰热蕴肺；慢性阻塞性肺疾。患毙约又仄冢谎字⒁蜃樱荒δ苤型挤掷嗪：R256.14；R562.2 + 5 文献标志码：A 文章编号：1007-3213（2019）02 - 0181 - 05DOI：10. 13359/j. cnki. gzxbtcm. 2019. 02. 006Effects of Self-prescribed Modified Gualou Xiebai Banxia Decoction onInflammatory Factors and Blood Coagulation Function of Patients atAcute Exacerbation Period of Chronic Obstructive Pulmonary Diseasewith Phlegm-heat Accumulating Lung TypeHUANG Chu-Yan 1 ， LIANG Hong-Yu 2(1.Chinese Medicine Section of Dept. of Pharmacy，the First Affiliated Hospital of Guangzhou University of Chinese Medicine，Guangzhou 510405 Guangdong，China；2. Section 2 of Dept. of Cardiovascular and Cerebrovascular Diseases，Guangzhou 510095 Guangdong，China.）Abstract：Objective To explore the effects of self-prescribed modified Gualou Xiebai Banxia Decoction（GXBD）on inflammatory factors and blood coagulation function of patients at acute exacerbation period of chronicobstructive pulmonary disease（COPD）with the syndrome of phlegm-heat accumulating lung. Methods A total of132 qualified patients were randomized into trial group and control group，66 cases in each group. Both groupswere given conventional western medicine treatment，and additionally the trial group was given modified GXBDorally，the treatment lasting 2 weeks. Before and after treatment，lung function indexes，inflammation factors，and blood coagulation function indexes in the two groups were observed，and the curative effect of the two groupswas compared after treatment. Results（1）After treatment for 2 weeks，the total effective rate in the trial group was74.24% and that in the control group was 45.45% ，the effect of the trial group being superior to that of the controlgroup（P＜0.01）.（2）After treatment， lung function indexes， inflammation factors， and blood coagulationfunction indexes in the two groups were much improved（P＜0.01 compared with those before treatment）；exceptfor the thrombin time（TT），the improvement of the above indexes in the trial group was superior to that of the广州中医药大学学报Journal of Guangzhou University of Traditional Chinese Medicine2019 年 2 月第 36 卷第 2 期February 2019，Vol. 36，No. 2 181