POBox2345, Bei j i ng100023, Chi naw w w ．w j gnet．tom州g@ w j gnet．comW orl d，GastroenterolW orl d／ournal ofGastroenterol ogy ISSN1007- 9327@ 2006 TheW IGPress．Al lri ghtsreserved．2006February乃12( 5) ：739-746Mi croproteinuri a i npati entsw i th i nfl amm atorybow el di sease：IS i t associ ated w i th the di sease acti vi ty or the treatm entw i th5· · am i nosal i cyl i caci d?Androni kiAndroni kiG eorgoul iCPoul oufKonstanti nos E G oum as，D i m i tri os C D andaki sf Ioanni sTyrm pasfM ari aPanagi otaki flD i m i tri os C SoutoslAthanasi os Archi m andri ti sAndroni kiD andaki s，Ioanni s Tyrm pas，M ari a Panagi otaki ，Androni kiG eorgoul i ，Di m i tri osCSoutos，G astroenterol ogy D epartm entof Red Cross H ospi tal of Athens，AthanasakiG reeceAthanasi osArchi m andri ti s，2” Departm entof Intem al M edi ci ne，U ni versi tyof Athens M edi calSchool “ H i ppokrati o” G eneralH ospi tal ，l1521 Athens，G reeceCorrespondence to：D r Androni ki Poul ou．Red Cross H ospi talof Athens，Spetson25，Voul a，16673 Athens，G reece．ddandaki s@ yahoo．tomTel ephone：+30· · 210· -6414724Recei ved：2005· -07--03C Poul ou，Konstanti nos E G oum as，D i m i tri os C1，1152 1 Athens，Fax：+30· · 210--6414635Accepted：2005· · 07· · 20AbstractAIM ：Toi nvesti gate w hether m i croprotei nuri a i n pati entsw i th i nfl am m atory bow eldi sease( IBD) i sassoci ated w i ththe di seaseacti vi tyor the treatm ent w i th5-am i nosal i cyl i caci d(5-ASA)-CO N CLU SIO N ：M i crO protei nuri a i s m ai nl y associ atedw i th U C and i tsacti vi tybut not affectedby5-ASA．④2006The W J GPress．Al lri ghtsreserved．Key w ords：Inf l am m atorybow eltei nuri a；5-am i nosal i cyl i caci ddi sease；M i cropro-PouIou AC，G oum as KE，D andaki s D C，Tyrm pasPanagi otakiM ，G eorgoul iA。M i croD rotei nuri adi sease：Istreatm ent w i th5-am i nosal i cyl i c aci d?W orl d 3 G astroenterol2006；12( 5) ：739—746I，A，Soutos D C，Archi m andri ti s．i npati entsw i thi nfl am m atorybow eIit associ ated w i th the di sease acti vi ty or the旗赣獭缫◇ 嘲曛◇ @ 麟唆—豢豢嚷魏襄凑赣i 荔≤滋鬻试N’ ’ T?蠢66b芑诵i：ji丽?一?一?一一～+一一一?一一’ 一?‘ 一。一。一。一。～??一一?一一M ETH oD S：W e prospecti vel y studi ed m i crO protei nuri ai n 86 consecuti ve pati ents w i th l BD ．61 w i th ul cerati vecol i ti s( U C) and 25 w i thCrohn’ sdi sease( CD) ，beforeasw el las 2 and 6 m onths after thei r i ncl usi on i n the study．FO 广tV-si x pati ents recei ved 5- ASA form onths( range1-1 68m o) ．M i croal bum i nuri a( m ALB) anduri ne Ievel s of the renaI tubul ar protei ns 132一m i crogl obul i n( 182m G LB) and 13-N -acetyl ．D．gl ucosam i dase( 13．N AG) asw el Ias the creati ni ne cl earance w ere determ i ned i n1 2-hoverni ghturi ne col l ecti on．Tum or necrosi s factor-e( TN F—o) serumIevel s w ere al so m easured．a peri od of 28．8aRESU LTS：A total ．of 277 m easurem ent spati entsand 83 In CDpati entslw ereperf orm ed．Thepreval enceof abnorm aIm i croprotei nuri apati ents w as27．7％for 132m G LB，and 1 1．3％and 8．4％for B．N AG，respecti vel y．m ALBw as not associ ated w i th IBDacti vi ty．B2m G LBand B—N AG uri ne l evel s w ere correl ated to U Cacti vi ty( U CAI：P<0．01：U CEI：P<0．005) ．m ALBi n U Cpati ents and 13-N AG uri ne Ievel srel ated to TN F- o seruml evel s．An associ ati on w asnoti ced betw een m i cr0D rO tei nur．a and sm oki ng habi t．Treatm ent w i th 5- ASA w as not correl ated to the severi tyO f m i cr0D rotei nuri a or to thechangesof creati ni necl earance．rI 94 i n U Ci n U C and CD1 2．9％and 6．0％for m ALB．22．7％andi n CDpati ents w ereCom pl i cati onsof theuri nary systemare not uncom m oni npati ents谢dl i nfl am m atory bow el di sease( IBDl ．Thei ri nci dence has beenreportedto varv f rom4％to 23％and113pauentsw i th m ore severe andl ong-standi ngdi seaseIIJ ．Apartf romsecondary com pl i cati ons，suchnephrol i thi asi s，hydronephrosi sandam yl oi dosi s，otherassoci ati ons betw een I BD and renal di sorders have al sobeen descri bed，regardl ess of treatm ent瞄～．M em branousi sgreat，e．、rasgl om erul onephdti s，rapi dl y progressi ve gl om erul onephri ti s，m esangi ocapi l l ary gl om erul onephri ti s，IgA nephropathy,thi n basem ent m em brane di sease andki dney Rranul om aare connectedw i th I BD pl uJ ．Inaddi ti on．non—speci fi cm orphol ogi cal changesi n thegl om erul iw i th IBD ，such aspodocyteef f acem ent andm esangi aldeposi ti onofi m m unogl obul i n and com pl em ent haveal so been w el l docum ented【J 11．O n thecont rary, casesofi ntersti ti alnephri ti s are attri buted to the nephrotoxi ceffect ofam i nosal i cyl ates¨ 11．H ow ever，bef ore theestabl i shm ent of 5—ASA as a treatm ent of choi ce i n IBD．studi es have i denti fi ed renal tubul ar l esi ons i n aproporti onofpati entsl ? ．Ti l ldate．m ore than 37 casesi m pfi cati ngthe drugi n i ntersti ti al nephri ti s( m ai nl y m esal azi ne butal so sul fasal azi ne，bal sal azi de，and ol sal azi ne) have beenreported t o the Com m i t t ee on Safety of M edi ci nes忙SM )哆ofpati entsw w w ．w j gnet．corn 万方数据
