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1 3Eur J Nutr (2017) 56:1157–1168DOI 10.1007/s00394-016-1165-5ORIGINAL CONTRIBUTIONDietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non?smoking postmenopausal women from the EPIC cohortMireia Obón?Santacana 1 · Leila Lujan?Barroso 1 · Heinz Freisling 2 · Claire Cadeau 3,4,5 · Guy Fagherazzi 3,4,5 · Marie?Christine Boutron?Ruault 3,4,5 · Rudolf Kaaks 6 · Renée T. Fortner 6 · Heiner Boeing 7 · J. Ramón Quirós 8 · Esther Molina?Montes 9,10 · Saioa Chamosa 11 · José María Huerta Castaño 10,12 · Eva Ardanaz 10,13 · Kay?Tee Khaw 14 · Nick Wareham 15 · Tim Key 16 · Antonia Trichopoulou 17,18 · Pagona Lagiou 19,20 · Androniki Naska 17,19 · Domenico Palli 21 · Sara Grioni 22 · Rosario Tumino 23 · Paolo Vineis 24,25 · Maria Santucci De Magistris 26 · H. B. Bueno?de?Mesquita 25,27,28,29 · Petra H. Peeters 25,30 · Maria Wennberg 31 · Ingvar A. Bergdahl 32 · Hubert Vesper 33 · Elio Riboli 25 · Eric J. Duell 1 Received: 24 July 2015 / Accepted: 22 January 2016 / Published online: 5 February 2016 © Springer-Verlag Berlin Heidelberg 2016(HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods Biomarkers of internal exposure were meas-ured in red blood cells (collected at baseline) by high-per-formance liquid chromatography/tandem mass spectrom-etry (HPLC/MS/MS) . In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome vari-ables. All dependent variables (except HbGA/HbAA) and Abstract Purpose Acrylamide was classif i ed as ‘probably carci-nogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identif i ed in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and life-style variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide Electronic supplementary material The online version of this article (doi:10.1007/s00394-016-1165-5) contains supplementary material, which is available to authorized users. * Eric J. Duell eduell@iconcologia.net1 Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (ICO-IDIBELL), Avda Gran Via Barcelona 199-203, L’Hospitalet de Llobregat, 08908 Barcelona, Spain2 Dietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France3 Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health Team, Inserm, 94805 Villejuif, France4 UMRS 1018, Université Paris Sud, 94805 Villejuif, France5 Institut Gustave Roussy, 94805 Villejuif, France6 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany7 Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114/116, 14558 Nuthetal, Germany8 Public Health and Participation Directorate, Ciriaco Miguel Vigil 9, 33009 Asturias, Spain9 Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs. GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Cuesta del Observatorio, 4, Campus Universitario de Cartuja, 18080 Granada, Spain10 CIBER Epidemiology and Public Health CIBERESP, Melchor Fernández Almagro 3-5, 28029 Madrid, Spain11 Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, Avda. Navarra, 4, 20013 San Sebastián, Spain12 Department of Epidemiology, Murcia Regional Health Authority, Ronda de Levante, 11, 30008 Murcia, Spain13 Navarre Public Health Institute, Polígono de Landaben C/F, 31012 Pamplona, Spain