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CMYK326基于大规模GWAS数据揭示遗传调节下免疫细胞特征与银屑病的关系临床皮肤科杂志2025年54卷第6期JClinDermatol,June2025,Vol.54,No.6论著高美蓉，范丹洋，曹继思，吕莎，李福秋吉林大学第二医院皮肤科，吉林长春130000[摘要】目的：旨在揭示免疫细胞特征与银屑病之间的关联。方法：使用孟德尔随机化(Mendelian randomization，M R)遗传学分析方法，利用免疫细胞特征相关基因多态性作为工具变量（instrumental variables,IVs），基于芬兰全基因组关联分析(genome-wide association study,GWAS)大数据，评估731种免疫细胞特征与银屑病之间的潜在遗传学关系。使用逆方差加权(inverse-variance weighted,IVW)法及其他验证方法,并进行敏感性分析以评估结果稳定性。结果：共筛选出4种与银屑病相关的免疫细胞特征。其中,CD39+Treg细胞与银屑病风险呈正相关[0R=1.021,95%置信区间（confidenceinterval,CI)：1.002-1.040,P=0.021),CD33+HLA-DR+免疫细胞(OR=0.980,95%CI:0.963-0.997,P=0.022)、CD 25+B细胞(OR=0.966,95%CI:0.936-0.996,P=0.028)及CD40+单核细胞(0R=0.980,95%CI:0.962-0.999,P=0.038)均与银屑病风险下降相关。结论：本研究首次揭示了免疫细胞特征与银屑病之间的潜在因果关系，为理解银屑病的病理机制及开发针对性治疗策略提供新的科学证据。[关键词]银屑。幻庖呦赴幻系露婊痆中图分类号] R758.63doi:10.16761/j.cnki.1000-4963.2025.06.003Potential causal relationship between immune cell traits and psoriasis: a Mendelian randomizationbased on large-scale GWAS dataGAO Meirong, FAN Danyang, CAO Jisi, LV Sha, LI FuqiuDepartment of Dermatology, the Second Hospital of Jilin University, Changchun 130000, China[Abstract] Objective: To reveal the association between immune cell characteristics and psoriasis: Methods: Using Mendelianrandomization(MR) genetic analysis, immune cell characteristic-related gene polymorphisms were employed as instrumental vari-ables(IVs). Based on the large dataset from a Finnish genome-wide association study(GWAS), we assessed the potential ge-netic relationships between 731 immune cell characteristics and psoriasis. The inverse-variance weighted(IVW) method andother verification methods were used, along with a sensitivity analysis to assess the stability of the results. Results: Four typesof immune cells demonstrated direct associations. CD39+ Treg cells were positively associated with the risk of psoriasis(OR=1.021,95%CI:1.002-1.040, P=0.021). Conversely, CD33+ HLA-DR+ immune cells(0R=0.980, 95%CI:0.963-0.997, P=0.022), CD25+B cells(OR=0.966, 95%CI:0.936-0.996, P-0.028), and CD40+ monocytes(OR=0.980, 95%CI:0.962-0.99, P=0.038) were neg-atively associated with the risk of psoriasis. Conclusions: This study is the first to reveal the potential causal relationship be-tween immune cell characteristics and psoriasis, providing new scientific evidence for understanding the pathophysiologicalmechanisms of psoriasis and developing targeted treatment strategies.[Key words] psoriasis; immune cells; mendelian randomization[文献标识码] A [文章编号]1000-4963(2025)06-0326-05[J Clin Dermatol, 2025, 54(6):326-330]银屑病作为一种免疫介导的慢性复发性皮肤疾病受遗传及环境因素的共同影响，其病理特征包括T细胞异常活化及皮肤角质形成细胞过度增殖。本病在全收稿日期：2024-03-25修回日期：2024-11-01基金项目：吉林省科技发展计划项目（YDZJ202102CXJD074)；吉林省产业技术研究与开发项目（2022C043-4)通信作者：李福秋,Email:lifq@jlu.edu.cn球范围内影响超1.25亿人,未来15年发病及患病趋势仍呈上升状态。寻常性银屑病是最常见的类型，占比90%以上，主要特征为广泛的红斑、斑丘疹或斑块，表面覆有白色鳞屑。目前银屑病的治疗手段以药物治疗为主,本病尚无法根治且易复发。鉴于银屑病严重影响患者生活质量,开展免疫机制研究对开发新型治疗手段具有重要意义。银屑病的发病机制尚未明确,越来越多的研究表明,银屑病与免疫系统异常激活密切相关，