wcjd@wjgnet.com 世界华人消化杂志 2014年8月8日; 22(22): 3307-3315ISSN 1009-3079 (print) ISSN 2219-2859 (online) 临床经验 CLINICAL PRACTICE胰岛素样生长因子-1及其受体在胃癌中的表达及临床意义曹友红, 许春芳, 马 平, 张晓琦®■背景 资料胃 癌在我国 是最常见的 恶性肿瘤之一, 为常见癌症发生第2位及癌症死因第3位; 近5年, 我国 每年新发胃癌病例 达40万左右, 占全球发病率的42%, 且发病率以每年1.6%的幅度逐渐攀升; 胃癌早期 常无特异性临床表现, 绝大多数患者确 诊时已属中晚期, 预后较差. 因此寻找能灵敏预警胃 癌发生发展的 生物学标志显得尤为重要. 曹友红, 马平, 江苏省南京市高淳人民医院消化科 江苏省南京市 211300许春芳, 江苏省苏州 大学附属第一医院消化科 江苏省苏州市 215006张晓琦, 南京大学医学院附属鼓楼医院消化科 江苏省南京市 210008曹友红, 主治医师, 主要从事消化系肿瘤的基础及临床应用方向的研究. 江苏大学医学临床科技发展基金资助项目 , No. JLY20120104作者贡献分布: 此文课题思路及论文撰写由曹友红与许春芳完成; 实验部分由曹友红与马平完成; 许春芳与张晓琦负责全文理论指导; 数据分析由曹友红完成. 通讯作者: 许春芳, 教授, 主任医师, 21 5006, 江苏省苏州市姑苏区十梓街1 88号, 江苏省苏州市苏州大学附属第一医院消化科. xcf601 @1 63.com收稿日期: 201 4-05-22 修回日期: 201 4-06-1 0接受日期: 201 4-06-1 9 在线出版日期: 201 4-08-08Clinical significance of expression of IGF-1R and IGF-1 in gastric cancerYou-Hong Cao, Chun-Fang Xu, Ping Ma, Xiao-Qi ZhangYou-Hong Cao, Ping Ma, Department of Gastroenterology, People's Hospital of Gaochun, Nanjing 211300, Jiangsu Province, ChinaChun-Fang Xu, Department of Gastroenterology, the First Affliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, ChinaXiao-Qi Zhang, Department of Gastroenterology, the Drum Tower Hospital Affiliated to Nanjing University, Nanjing 210008, Jiangsu Province, ChinaSupported by: Jiangsu University Medical Clinical Sci-ence and Technology Development Fund, No. JLY20120104Correspondence to: Chun-Fang Xu, Professor, Chief Phy-sician, Department of Gastroenterology, the First Affliated Hospital of Soochow University, 188 Shizi Street, Gusu District, Suzhou 215006, Jiangsu Province, China. xcf601@163.comReceived: 2014-05-22 Revised: 2014-06-10 Accepted: 2014-06-19 Published online: 2014-08-08AbstractAIM: To investigate the expression of insulin-like growth factor type 1 receptor (IGF-1R) and IGF-1 in gastric cancer and to analyze the rela-tionship between their expression and the clini-copathologic features. METHODS: The expression of IGF-1R and IGF-1 proteins was detected by immunohis-tochemistry in 70 gastric cancer tissues and matched tumor adjacent tissues. The relation-ship between the expression of IGF-1R and IGF-1 and clinicopathologic parameters includ-ing gender, age, tumor diameter, site, differ-entiation, Borrmann type, infiltration depth, lymph node metastasis and TNM stage was then analyzed.RESULTS: The positive rates of IGF-1R/IGF-1 expression in gastric cancer (55.17%/52.86%) were significantly higher than those in con-trol tissue (25.00%/15.63%) (P < 0.05). IGF-1R expression was closely correlated with tumor differentiation, infiltration depth, lymph node metastasis and TNM stage (P < 0.05). IGF-1 ex-pression was closely correlated with tumor infl-tration depth, lymph node metastasis and TNM stage (P < 0.05). The expression of IGF-1R was positively correlated with that of IGF-1 in gastric cancer (r = 0.310, P < 0.01). CONCLUSION: Over-expression of IGF-1R exists in gastric cancer and is correlated with tumor differentiation, infltration depth, lymph node metastasis and TNM stage. Over-expres-sion of IGF-1 also exists in gastric cancer and is correlated with infltration depth, lymph node metastasis and TNM stage. Overexpression of IGF-1R and IGF-1 may be related to the devel-opment of gastric cancer. There is a positive cor-relation between IGF-1R and IGF-1 expression in gastric cancer, suggesting a synergistic effect between them in the development of gastric cancer. They may become new markers for gas-tric cancer.© 2014 Baishideng Publishing Group Inc. All rights reserved. Key Words: Insulin-like growth factor type 1 recep-tor; Insulin-like growth factor type 1; Gastric can-cer; ImmunohistochemistryCao YH, Xu CF, Ma P, Zhang XQ. Clinical signifcance of expression of IGF-1R and IGF-1 in gastric cancer. Shijie Huaren Xiaohua Zazhi 2014; 22(22): 3307-3315 URL: http://www.wjgnet.com/1009-3079/22/3307.asp DOI: http://dx.doi.org/10.11569/wcjd.v22.i22.3307 ■同 行评议者傅红, 副 教授, 上海复旦大学肿瘤医院肿瘤外科2014-08-08| Volume 22| Issue 22|WCJD| www.wjgnet.com
