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DRUG REACTIONS AND INTERACTIONSFirst reports of serious adverse drug reactions in recent weeksPublished online: 21 August 2013? Springer International Publishing Switzerland 2013The following table contains an overview of first publishedcase reports of serious adverse drug reactions identified inthe international literature in recent weeks by the drugsafety alerting service Reactions Weekly. An event isserious (US FDA MedWatch definition) when the patientoutcome is death, life threatening, hospitalization, disabil-ity, congenital anomaly or requires intervention to preventpermanent impairment or damage. Reactions and thecustomized Reactions Pharmacovigilance Service areproduced by Adis, and monitor[4000 journals, includingrelevant MEDLINE- and EMBASE-indexed journals, aswell as companion journal supplements, major scientificmeetings, the newsletters from the [80 national centresparticipating in the WHO International Drug MonitoringProgramme, media releases, pharmaceutical companywebsites, and regulatory agency websites.Drug and serious adverse reactionReferenceAceclofenac: acute tubulointerstitial nephritisGupta M, Cruz SD, Nada R, et al. Aceclofenac-induced acute tubulointerstitialnephritis in a patient with diabetes. BMJ Case Rep. 2013; pii:bcr2013009217.Agomelatine: deliriumViejo Sacha MG, De Ambrosi B, Mun˜oz C, et al. Two cases of delirium withagomelatine therapy. Ann Clin Psychiatry. 2013;25(1):67–8.Baclofen: increased blood triglyceride levelsClarisse H, Imbert B, Belzeaux R, et al. Baclofen and risperidone associationincreases dramatically triglycerides level. Alcohol Alcohol. 2013;48(4):515–6.Ceftaroline fosamil: agranulocytosis in an elderly patientRimawi RH, Frenkel A, Cook PP. Ceftaroline: a cause for neutropenia. J ClinPharm Ther. 2013;38(4):330–2.Colistin: contact tracheobronchitisVogel S, Varga R, Friedl T, et al. Respiratory insufficiency due to contact allergyto colistin [abstract no. 808]. Allergy. 2012;67 Suppl S96:313-4.Insulin detemir: interactions with amoxicillin, clarithromycin andomeprazole leading to hypoglycaemia in an elderly patientOtsuka SH. Severe hypoglycemia from Helicobacter pylori triple-drug therapyand insulin detemir drug interaction. Pharmacotherapy. 2013;33(4):e45–9.Linagliptin/vildagliptin: hepatitis in an elderly patientDanish Health and Medicines Authority. Acute pancreatitis and hepatitisassociated with the use of vildagliptin (Galvus?) and linagliptin (Trajenta?)reported as potential adverse reactions. Dan Pharmacovig Update. 2013;4(6):5.Phenylephrine: type IV reaction manifesting as drughypersensitivity syndromeRice SA, Swale VJ, Haque R, et al. Erythroderma in the emergency department.BMJ. 2013;346:f3613.Tocilizumab: hepatitisAlfreijat M, Habibi M, Bhatia P, et al. Severe hepatitis associated withtocilizumab in a patient with rheumatoid arthritis. Rheumatology (Oxford).2013;52(7):1340–1.Tocilizumab: mesangial proliferative glomerulonephritisMatsuo Y, Mizoguchi F, Kohsaka H, et al. Tocilizumab-induced immunecomplex glomerulonephritis in a patient with rheumatoid arthritis.Rheumatology (Oxford). 2013;52(7):1341–3.Valproate: panhypogammaglobulinaemia in an infantEom TH, Lee HS, Jang PS, et al. Valproate-inducedpanhypogammaglobulinemia. Neurol Sci. 2013;34(6):1003–4.Vemurafenib: pancreatitisMuluneh B, Buie LW, Collichio F. Vemurafenib-associated pancreatitis: casereport. Pharmacotherapy. 2013;33(4):e43–4.Drugs Ther Perspect (2013) 29:320DOI 10.1007/s40267-013-0070-8