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Synthesis and characterization of a novel amphiphilic biodegradableb-cyclodextrin/poly(g-benzyl L-glutamate) copolymerQiu Hua Wua,b, Fang Lianga,b, Tian Zhu Weia,b, Xi Ming Songa,b,Shu Yao Wua,b, Guo Lin Zhanga,b,*aKey Laboratory ofGreen Synthesis and Preparative Chemistry ofAdvanced Materials (Liaoning University),The Education Department ofLiaoning Province, Shenyang 110036, ChinabCollege ofChemistry, Liaoning University, Shenyang 110036, ChinaReceived 29 August 2008Abstractb-Cyclodextrin/poly(g-benzyl L-glutamate) (b-CD-PBLG) copolymers were synthesized by ring-opening polymerization ofN-carboxy-g-benzyl L-glutamate anhydride (BLG-NCA) in N,N-dimethylformamide (DMF) initiated by mono-amino-b-cyclodex-trin(H2N-b-CD). The structures ofthe copolymers were confirmed by IR,1H NMR and GPC. The fluorescence technique was usedto determine the critical micelle concentrations (CMC) ofcopolymer micell solution, the diameter and the distribution ofmicelleswere characterized by DLS. The results showed that BLG-NCA could be initiated by H2N-b-CD to produce copolymer. The nano-micells were formed by these copolymers in water.# 2008 Guo Lin Zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.Keywords: b-Cyclodextrin; Poly(g-benzyl-L-glutamate); Amphiphilic biodegradable copolymers; Critical micelle concentrationRecently, much attention has been paid to the amphiphilic biodegradable polymers because both biodegradabilityand amphiphilicity are extremely significant properties for some applications of biomedical polymers. Theamphiphilic biodegradable polymers may be used as controlled release of drug implants and proteins, scaffolds fortissue engineering and medical devices [1,2]. Poly(a-amino acid)s (PAA) are well known as very important syntheticbiodegradable materials, which can be synthesized by means of ring-opening polymerization of a-amino acid N-carboxyanhydrides (NCA) initiated by primary amine [3]. Due to their low immunogenicity, good biocompatibilityand excellent mechanical properties, they may be widely used in pharmaceutical and other medical applications [4,5].But generally speaking, it is rather hydrophobic, and it degrades very slowly by simple hydrolysis under the humanbody conditions. In order to improve the hydrophilicity and control the biodegradable rate of these poly(a-aminoacid)s, one may introduce hydrophilic pendant functional groups into the polymer chain.b-Cyclodextrin (b-CD) is acyclic oligosaccharide containing sevenglucopyranose units, it has low toxicity, certainhydrophilicity, excellent biocompatibility and biodegradability [6,7]. One of the most remarkable applications of b-CD is its use as drug carriers in controlled release systems. As drug carriers, b-CD allows the solubilization, thewww.elsevier.com/locate/ccletAvailable online at www.sciencedirect.comChinese Chemical Letters 20 (2009) 362–365* Corresponding author at: College of Chemistry, Liaoning University, Shenyang 110036, China.E-mail address: glzhang@lnu.edu.cn (G.L. Zhang).1001-8417/$ –see front matter # 2008 Guo Lin Zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.doi:10.1016/j.cclet.2008.11.016万方数据