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REVIEW BODY CONTOURINGLaser-Assisted Lipolysis: A Promising Alternative to TraditionalLiposuctionAlexander Manzano-Finol 1,7 • Heliana Parra-Pelosi 1 • Gabriel Cubillos-Valencia 2 •Juan Urdaneta 3 • Diego Rivera-Porras 4 • Maricarmen Chac? ´n 5 • Valmore Bermu´dez 5,6Received: 21 February 2025/Accepted: 11 June 2025/Published online: 6 August 2025? The Author(s) 2025AbstractBackground Laser-Assisted Lipolysis (LAL) has emergedas a modern advancement in body contouring, offeringsolutions to limitations of traditional liposuction such asprolonged recovery, increased bruising, and limited skin-tightening effects. By using targeted laser energy to liquefyfat before removal, LAL minimizes tissue trauma, enhan-ces skin retraction, and improves overall aestheticoutcomes.Objective To provide a comprehensive review of the his-torical evolution, current technological advances, compar-ative methodologies, limitations, and future directions ofLAL in cosmetic surgery.Methods A narrative literature review was conducted,incorporating peer-reviewed articles, FDA-cleared devices,and clinical studies. Topics included the historical pro-gression of LAL since its inception in the late 1990s,comparative analyses between LAL and traditionaltechniques, evaluation of laser wavelengths (e.g., 1064,1320, 1444, and 1470 nm), and examination of innovationssuch as dual-wavelength systems, robotic-assisted delivery,AI-guided planning, and radiofrequency-assisted methods.Results LAL shows clinical advantages including fasterrecovery times, reduced postoperative pain, and improvedskin tightening, especially in small to moderate fat reduc-tion areas. Dual- and multi-wavelength lasers, pulse mod-ulation, and f i ber-optic temperature sensing improveprecision and safety. Comparative studies show LALachieves better outcomes than traditional liposuction incertain contexts, particularly for skin appearance and sub-mental fat reduction. However, variability in laser param-eters, higher procedural costs, and limitations in autologousfat reuse remain concerns. Research also highlightspromising applications of LAL in large-volume fat removaland potential bariatric contexts.& Valmore Bermu´dezvalmore.bermudez@unisimon.edu.coAlexander Manzano-Finolamanzanof i nol@health.unm.eduHeliana Parra-Pelosihelianapp@hotmail.comGabriel Cubillos-Valenciadrgabrielcubillosv@gmail.comJuan Urdanetajuancaurdaneta@gmail.comDiego Rivera-Porrasdrivera23@cuc.edu.coMaricarmen Chac? ´nmaricarmen.chacing@unisimon.edu.co1Endocrine and Metabolic Diseases Research Center, Schoolof Medicine, Universidad del Zulia, Maracaibo 4002,Venezuela2Cl? ´nica de Obesidad y Envejecimiento, Bogota ´, Colombia3Mental Health Clinic, Insight Mental Wellness, San Antonio,Texas 78217, USA4Departamento de Productividad e Innovacion, Universidad dela Costa, 080001 Barranquilla, Atlantico, Colombia5Facultad de Ciencias de la Salud, Universidad Simo´n Bol? ´var,080001 Barranquilla, Colombia6Centro de Investigaciones en Ciencias de la Vida,Universidad Simo´n Bol? ´var, 080001 Barranquilla, Colombia7Internal Medicine Department, University of New Mexico,Albuquerque, USA123Aesth Plast Surg (2025) 49:5522–5531https://doi.org/10.1007/s00266-025-05056-8