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上传于：2016-03-14

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    188宝金博页面版: Uric Acid Lowering to Prevent Kidney Function Loss in Diabetes： The Preventing Early Renal Function Loss (PERL) Allopurinol Stud

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    内容提示： MICROVASCULAR COMPLICATIONS-NEPHROPATHY (B ROSHAN, SECTION EDITOR)Uric Acid Lowering to Prevent Kidney Function Lossin Diabetes: The Preventing Early Renal Function Loss(PERL) Allopurinol StudyDavid M. Maahs & Luiza Caramori & David Z. I. Cherney & Andrzej T. Galecki &Chuanyun Gao & Diana Jalal & Bruce A. Perkins & Rodica Pop-Busui & Peter Rossing &Michael Mauer & Alessandro Doria & on behalf of the PERL ConsortiumPublished online: 7 May 2013# Springer Science+Business Media New York 2013Abstract Diabetic ...

    文档格式：PDF | 页数：10 | 浏览次数：413 | 上传日期：2016-03-14 00:08:57 | 文档星级：
    MICROVASCULAR COMPLICATIONS-NEPHROPATHY (B ROSHAN, SECTION EDITOR)Uric Acid Lowering to Prevent Kidney Function Lossin Diabetes: The Preventing Early Renal Function Loss(PERL) Allopurinol StudyDavid M. Maahs & Luiza Caramori & David Z. I. Cherney & Andrzej T. Galecki &Chuanyun Gao & Diana Jalal & Bruce A. Perkins & Rodica Pop-Busui & Peter Rossing &Michael Mauer & Alessandro Doria & on behalf of the PERL ConsortiumPublished online: 7 May 2013# Springer Science+Business Media New York 2013Abstract Diabetic kidney disease causes significant mor-bidity and mortality among people with type 1 diabetes(T1D). Intensive glucose and blood pressure control havethus far failed to adequately curb this problem and thereforea major need for novel treatment approaches exists. Multipleobservations link serum uric acid levels to kidney diseasedevelopment and progression in diabetes and strongly arguethat uric acid lowering should be tested as one such novelintervention. A pilot of such a trial, using allopurinol, iscurrently being conducted by the Preventing Early RenalFunction Loss (PERL) Consortium. Although the PERLtrial targets T1D individuals at highest risk of kidney func-tion decline, the use of allopurinol as a renoprotective agentmay also be relevant to a larger segment of the populationwith diabetes. As allopurinol is inexpensive and safe, itcould be cost-effective even for relatively low-risk patients,pending the completion of appropriate trials at earlier stages.Keywords Uricacid . Kidneydisease . Diabetes .Diabetickidneydisease . Glomerularfiltrationrate .Allopurinol . Diabeticnephropathy . Randomizedclinicaltrial . Type1diabetes . PERLtrialD. M. MaahsBarbara Davis Center for Childhood Diabetes,University of Colorado Denver, Aurora, CO, USAD. M. Maahs : D. JalalDivision of Renal Diseases and Hypertension,University of Colorado Denver, Aurora, CO, USAL. Caramori : M. MauerDepartments of Pediatrics and Medicine,University of Minnesota, Minneapolis, MN, USAD. Z. I. CherneyDepartment of Medicine and Division of Nephrology,University of Toronto, Toronto, ON, CanadaA. T. GaleckiDivision of Geriatrics/Institute of Gerontology, Medical School,and Department of Biostatistics, School of Public Health,University of Michigan, Ann Arbor, MI, USAC. GaoJoslin Clinic, Joslin Diabetes Center, Boston, MA, USAB. A. PerkinsDepartment of Medicine and Division of Endocrinology,University of Toronto, Toronto, ON, CanadaR. Pop-BusuiDepartment of Internal Medicine, Division of Metabolism,Endocrinology and Diabetes, University of Michigan, Ann Arbor,MI, USAP. RossingSteno Diabetes Center, Gentofte, DenmarkP. RossingHEALTH, University of Aarhus, Aarhus, DenmarkP. RossingNNF CBMR University of Copenhagen, Copenhagen, DenmarkA. Doria (*)Section on Genetics and Epidemiology, Joslin Diabetes Center,One Joslin Place, Boston, MA 02215, USAe-mail: alessandro.doria@joslin.harvard.eduA. DoriaDepartment of Medicine, Harvard Medical School, Boston, MA,USACurr Diab Rep (2013) 13:550–559DOI 10.1007/s11892-013-0381-0

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