188宝金博页面版

DOI : １０． １３２１０ /j．cnki． jhmu． ２０１６０６３０． ００６网络出版地址:http :// www．cnki． net / kcms / detail / ４６． １０４９．R． ２０１６０６３０． １１５４． ０１２． html[基金项目]四川省卫生厅科研课题( １３０８５５ )[作者简介]蒋秀兰 ( １９７６Ｇ ),女,四川简阳人,电话: １３９８２９３８０３３ ,电子邮箱: jiangyongfengxj＠１６３．com .[收稿日期] ２０１６Ｇ０６Ｇ１６　　 [修回日期] ２０１６Ｇ０７Ｇ１４　　 网络出版时间: ２０１６Ｇ６Ｇ３０１１ : ５４围手术期应用 LＧ 精氨酸联合整蛋白复方制剂对胃癌患者术后抗肿瘤免疫及肿瘤负荷的影响蒋秀兰(四川省简阳市中医医院手术室,四川 简阳 。叮矗保矗埃 )　　 [摘要]目的:分析围手术期应用 LＧ 精氨酸联合整蛋白复方制剂对胃癌患者术后抗肿瘤免疫及肿瘤负荷的影响.方法: ６８ 例胃癌患者均接受根治性手术治疗,根据围术期营养干预不同分为对照组(常规葡萄糖盐水肠内营养)３４ 例、观察组( LＧ 精氨酸联合整蛋白复方制剂肠内营养) ３４ 例.检测两组术后近期抗肿瘤免疫细胞水平、血清病情相关指标、营养及炎症指标水平,并随访 ３ 年观察患者残胃 MRI 改变.结果:(１ )观察组治疗后 ３ 个月,静脉血 CD４＋ T 淋巴细胞水平,CD４＋ /CD８＋比值均高于对照组(P ＜０．０５ ), CD８＋ T 淋巴细胞、Treg 细胞水平低于对照组(P ＜０． ０５ );血清 PentraxinＧ３ 、 CYFRA２１Ｇ１ 、 TTFＧ１ 、HE４ 水平低于对照组( P ＜０． ０５ );白蛋白( ALB )、前白蛋白( PA )、白介素 Ｇ２ ( ILＧ２ )水平高于对照组,白介素 Ｇ６ (ILＧ６ )、白介素 Ｇ１０ ( ILＧ１０ )水平低于对照组( P ＜０． ０５ ).( ２ )两组患者术后 ３ 年残胃 MRI 图像存在显著差异.结论:围手术期应用 LＧ 精氨酸联合整蛋白复方制剂可优化胃癌患者术后免疫及营养状态,在降低远期残胃癌发生率等方面也有肯定性作用.[关键词]胃癌;LＧ 精氨酸;整蛋白复方制剂;抗肿瘤免疫[中图分类号] R７３５．２　 [文献标识码] B　 [文章编号] １００７Ｇ１２３７ ( ２０１６ ) １９Ｇ２３０５Ｇ０４EffectofperioperativeapplicationofL－asrgininecombinedwithintactedproteincompoundpreparationsonpostoperativeantitumorimmunityandtumorloadinpatientswithgastriccancerJIANGXiuＧlan( OperatingRoom , JianyangIntegratedTCM HospitalofSichuanProvince , JianyangCity ６４１４００ , SichuanProvince , China )[FoundationProject ]: ItissupportedbyResearchProjectofSichuanProvincialHealthDepartment ( １３０８５５ ) ．[ Author ]: JIANGXiuＧlan ( １９７６ Ｇ ), Female , JianyangSichuan , Tel : １３９８２９３８０３３ , EＧmail : jiangyongfengxj ＠ １６３．com ．Received : ２０１６ Ｇ ０６ Ｇ １６　　 Revised : ２０１６ Ｇ ０７ Ｇ １４ JHMC , ２０１６ ; ２２ ( １９ ): ２３０５ Ｇ ２３０８Viewfromspecialist : Itiscreative , andofcertainscientificandeducationalvalue．[ ABSTRACT ] Objective : ToanalyzetheeffectofperioperativeapplicationofLＧargininecombinedwithintactedproteincompoundpreparationsonpostoperativeantitumorimmunityandtumorloadinpatientswithgastriccancer．Methods : Atotalof６８patientswithgastriccancerreceivedradicaloperation , andaccordingtodifferentperioperativenutritionintervention , theyweredividedintocontrolgroup ( normalglucosesalineenteralnutrition ) with３４casesandobservationgroup (LＧargininecomＧbinedwithintactedproteincompoundpreparationsenteralnutrition ) with３４cases．PostoperativeshortＧtermantitumorimmunecelllevelsandserumlevelsofillnessＧrelatedindexes , nutritionandinflammationindexesoftwogroupsweredetected , patientswerefollowedupfor３yearsandthegastricstumpMRIchangeswereobserved．Results :( １ ) VenousbloodCD４＋ TlymphocytelevelandCD４＋ /CD８＋ ratioofobservationgroup３monthsaftertreatmentweresignificantlyhigherthanthoseofcontrolgroupwhileCD８＋ TlymphocyteandTregcelllevelsweresignificantlylowerthanthoseofcontrolgroup (P ＜０． ０５ ); serumPentraxＧinＧ３ , CYFRA２１Ｇ１ , TTFＧ１andHE４levelsweresignificantlylowerthanthoseofcontrolgroup ( P ＜０． ０５ ); ALB , PAandILＧ２levelsweresignificantlyhigherthanthoseofcontrolgroupwhileILＧ６andILＧ１０levelsweresignificantlylowerthanthoseofcontrolgroup ( P ＜０．０５ ) ． ( ２ ) Gastricstump MRIimages３yearsafteroperationweresignificantlydifferentbetweentwo５ ０ ３ ２海南医学院学报 。玻埃保 , ２２ ( １９ )JournalofHainanMedicalUniversity