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EP 1 863 570 B12510152025303540455055DescriptionFIELD OF THE INVENTION[0001] The present invention relates to therapeutically active and health benefiting selective oil formulation and, inparticular, to a health benefiting dietary edible oil formulation providing for selective and surprising efficacious and stableretention of highly unsaturated and highly unstable benefit actives Eicosa Pentaenoic acid (EPA) and Docosa HexaenoicAcid (DHA) even at normal cooking temperature for safe and healthy regular administration/ consumption by humans.The dietary edible oil of the invention on one hand avoids the limitations of the use of EPA/DHA in edible oils due toproblems of impurity in the sources for such health benefiting actives EPA/DHA presently available and on the otherhand takes care of providing the much desired alternative media for regular administration / consumption by humansincluding such beneficial actives and health preventing cardio-vascular ailments especially those related to high triglyc-eride and cholesterol in humans including reducing stickiness in blood vessels / walls. The invention is also directed tothe finding that EPA / DHA can be heat stable and hence can be advantageous and incorporated in desired amountsin dietary edible oils for cooking purposes and thereby provide for a cooking media good for the health and well-beingof individual. The invention is further directed to the method of treating humans for maintaining good health by way ofregular consumption / administration into humans of the health benefiting dietary edible oil incorporating such activesEPA / DHA.BACKGROUND ART[0002] It is well known that accumulation of excess cholesterol and triglycerides are two known predictors for coronaryrisk and a study conducted by WHO put more emphasis on excess triglyceride which appears to be a stronger predictorfor coronary mortality.[0003] It is known that low density lipo-protein (LDL) is a derivative of ingested oil which carry cholesterol to the cells(normal body function) irrespective of body requirements. On the other hand high density Lipo-protein (HDL) anotherderivative of ingested oil transports back excess cholesterol to liver for disposal.[0004] Therefore in order to maintain cholesterol levels within the normal range and also reduce triglyceride levels incerium lipid, it is desirable to have reduced level of LDL and increased level of HDL. The ratio that is total cholesteroldivided by HDL, is therefore an important criteria, and lower the ratio better it is.[0005] It is anticipated that because of life style changes, a very large section of the population is likely to have cardio-vascular problems, and dietary edible oils and their quality and characteristics play an important role in maintaining thehealth and fitness of humans especially those used to regular consumption of food cooked with such presently availabledietary edible oils.[0006] Clinical trials conducted by national institute of nutrition, Hyderabad, India have further proved beyond doubtthat conventional ingredients of dietary oils such as Mono saturated fatty acids (MUFA) oleic (n-9), Poly unsaturatedfatty acid (PLTFA) - linoleic (n-6) and Alpha linolenic acid (ALNA) (n-3) i.e. normal oils and fats used for cooking includingsafflower oil, soyabean oil, groundnut oil, canola oil, etc- cannot reduce triglyceride levels in cerum lipid.[0007] Therefore it has been the requirement in the art to provide dietary cooking oils having beneficial effects namelyreduction of LDL and / or increase in HDL or the ratio of cholesterol and direct HDL reduction of triglyceride level andreduction of tendency of platelets to clump and adhere to the blood vessel walls due to lower cholesterol levels andrelated contraction of the blood vessel themselves would go a long way for overall health care as oils are used daily andby all members of the family.[0008] It is known that Eicosa Pentaenoic Acid (EPA) and Docosa Hexaenoic Acid (DHA) - have therapeutic valuesas active capable of reducing the cholesterol level in the body and favour maintaining good health conditions especiallyby safeguarding against coronary risks associated with high triglyceride / cholesterol levels in the body.[0009] However, inspite of the above known therapeutic values of EPA/ DHA so far their use has been mostly restrictedto its use in encapsulated / protected form as capsules because of possible instability in contact with air / moisture dueto its highly unsaturated constitution / characteristic. It is known that heat is extremely damaging to any polyunsaturatedoil. It serves to break their precious double bonds changing the oil from a healthy and safe known constitution into anunhealthy unknown constitution. These effects magnify as cooking temperature increases.[0010] The poly unsaturated fatty acids DHA / EPA therefore also have problems due to their high degree of unsaturationwhich call for treatments to increase stability against oxidation and / or through elimination of important part of theconstitution of the oil resulting in loss in its nutritional value.[0011] US6235331 reports on a modified fish oil containing highly unsaturated fatty acids and/ or its esters such asDHA or EPA which does not have an offensive odor and maintains an odorless state after preserved for a long time thatis obtained essentially by adding vinegar or citrus fruit juice to highly unsaturated acid or ester derived from fish oil whichis then allowed to settle so as to separate the oil phase and the said modified fish oil is then recovered after removal of