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IJRPC 2011, 1(4) Roopa rani et al. ISSN: 2231? ?2781 1046 INTE RNATIONAL J OURNAL OF RESEARCH IN PH ARMACY AND CH EMISTRY Available online at www.ijrpc.com SOLUBILIZED FORMULATION AND EV ALUATION OF LIQUID FILLED HARD GELATIN CAPSULES OF ESTROGEN RECEPTOR MODULATOR DRUG Roopa rani Balivada* Flat no: 61, Block D2, Shanthi Shikara Appartment, Somajiguda, Hyderabad, Andhra Pradesh, India. *Corresponding Author: rooparani_elluisve@yahoo.co.in INTRODUCTION Liquid filled hard gelatin capsule are well established as a solid dosage form for convenient administration of drugs orally in a liquid form. Liquid filled capsule technology can be used for liquid and semisolid fills in two piece gelatin or HPMC capsule with or without banding. This range of liquid composition available to accommodate even the most challenging drug compounds in capsules has increased significantly in recent years. In particular it is possible to solubilize many drug compounds in a micro emulsion pre-concentrate inside the hard gelatin capsules such that on subsequent dispersion in the gastro intestinal tract, the drug remains in Research Article ABSTRACT Estrogen replacement is considered the first line approach for the prevention and treatment of multiple conditions affecting women’s health. It has been widely recommended for prevention and treatment of osteoporosis. However its long term use is not without risks. Hence patients prefer to be treated with non-hormonal drugs. Raloxifene is one of a new generation of drugs called selective estrogen receptor modulator (SERM) specifically developed to maintain beneficial estrogenic activity on bone and lipids and antiestrogenic activity on endometrial and breast cancer tissue. At present it is the only SERM approved for treating and preventing osteoporosis in postmenopause women. The major problem encountered with this drug was its poor aqueous solubility. Since dissolution is the rate determining step for hydrophobic, poor aqueous soluble drug, absorption of such drugs is often said to be dissolution rate-limited. To design proper dosage regimen and to improve oral bioavailability efforts were made to solubilize the drug. Liquid filled hard gelatin capsule are well established as a solid dosage form for convenient administration of drugs orally in a liquid form in two piece HPMC capsule. This technology is more adopted for insoluble hydrophobic and potent drugs. And there are also many advantages in giving the drug in liquid form. Hence drug compounds are solubilised inside the hard gelatin capsules such that on subsequent dissolution of LFHGC in the gastro intestinal tract, the drug remains in solution, and contribute for good bioavailability of drugs. Keywords: Hydrophobic, Solubilization, Complex, Solvets.