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上传于：2020-09-25

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毕业于985学校的汽车工程专业，毕业后一直从事汽车工程技术研究

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    188宝金博页面版: A mass spectrometry-guided genome mining approach for natural product peptidogenomics

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    内容提示： A mass spectrometry-guided genome mining approach for natural product peptidogenomicsRoland D. Kersten 1 , Yu-Liang Yang 2 , Yuquan Xu 2 , Peter Cimermancic 3 , Sang-Jip Nam 1 , William Fenical 1,2 , Michael A. Fischbach 3 , Bradley S. Moore 1,2,* , and Pieter C. Dorrestein 1,2,4,*1) Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California, USA2) Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Cali...

    文档格式：PDF | 页数：21 | 浏览次数：16 | 上传日期：2020-09-25 05:35:38 | 文档星级：
    A mass spectrometry-guided genome mining approach for natural product peptidogenomicsRoland D. Kersten 1 , Yu-Liang Yang 2 , Yuquan Xu 2 , Peter Cimermancic 3 , Sang-Jip Nam 1 , William Fenical 1,2 , Michael A. Fischbach 3 , Bradley S. Moore 1,2,* , and Pieter C. Dorrestein 1,2,4,*1) Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California, USA2) Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California, USA3) Department of Bioengineering and Therapeutic Sciences and California Institute of Quantitative Biosciences, University of California, San Francisco, USA4) Department of Pharmacology and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California, USAAbstractPeptide natural products exhibit broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes. To harvest this large and diverse resource of bioactive molecules, we introduce Natural Product Peptidogenomics (NPP), a new mass spectrometry-guided genome mining method that connects the chemotypes of peptide natural products to their biosynthetic gene clusters by iteratively matching de novo MS n structures to genomics-based structures following current biosynthetic logic. In this study we demonstrate that NPP enabled the rapid characterization of >10 chemically diverse ribosomal and nonribosomal peptide natural products of novel composition from streptomycete bacteria as a proof of concept to begin automating the genome mining process. We show the identification of lantipeptides, lasso peptides, linardins, formylated peptides and lipopeptides, many of which from well-characterized model streptomycetes, highlighting the power of NPP in the discovery of new peptide natural products from even intensely studied organisms.Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms* to whom correspondence should addressed: pdorrestein@ucsd.edu. * bsmoore@ucsd.edu.. Author contributions R.D.K. designed and carried out experiments, analyzed data and wrote the paper. Y.L.Y., Y.X. and S.J.N. carried out experiments and analyzed data. P.C. and M.A.F. carried out the bioinformatic analysis and analyzed data. W.F. analyzed data. B.S.M and P.C.D. designed experiments, analyzed data and wrote the paper.Competing financial Interests The authors declare no competing financial interests.HHS Public AccessAuthor manuscriptNat Chem Biol. Author manuscript; available in PMC 2012 May 01.Published in final edited form as:Nat Chem Biol. ; 7(11): 794–802. doi:10.1038/nchembio.684.Author Manuscript Author Manuscript Author Manuscript Author Manuscript

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