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    188宝金博页面版: Transplants of Human Mesenchymal Stem Cells Improve Functional Recovery After Spinal Cord Injury in the Rat

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    内容提示： Cellular and Molecular Neurobiology, Vol. 26, Nos. 7/8, October/November 2006 (C ?2006)DOI: 10.1007/s10571-006-9093-1Transplants of Human Mesenchymal Stem Cells ImproveFunctional Recovery After Spinal Cord Injury in the RatDaˇ saˇC??ˇ zková,1,4Ján Rosocha,2Ivo Vanick? y,1Stanislava Jergová,1and MilanˇC??ˇ zek3Received December 6, 2005; accepted May 23, 2006; Published online: July 29, 2006SUMMARYHuman mesenchymal stem cells (hMSCs) derived from adult bone marrow repre-sent a potentially useful...

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    Cellular and Molecular Neurobiology, Vol. 26, Nos. 7/8, October/November 2006 (C ?2006)DOI: 10.1007/s10571-006-9093-1Transplants of Human Mesenchymal Stem Cells ImproveFunctional Recovery After Spinal Cord Injury in the RatDaˇ saˇC´?ˇ zková,1,4Ján Rosocha,2Ivo Vanick´ y,1Stanislava Jergová,1and MilanˇC´?ˇ zek3Received December 6, 2005; accepted May 23, 2006; Published online: July 29, 2006SUMMARYHuman mesenchymal stem cells (hMSCs) derived from adult bone marrow repre-sent a potentially useful source of cells for cell replacement therapy after nervous tissuedamage. They can be expanded in culture and reintroduced into patients as autograftsor allografts with unique immunologic properties. The aim of the present study was toinvestigate (i) survival, migration, differentiation properties of hMSCs transplanted intonon-immunosuppressed rats after spinal cord injury (SCI) and (ii) impact of hMSC trans-plantation on functional recovery. Seven days after SCI, rats received i.v. injection ofhMSCs (2×106in 0.5 mL DMEM) isolated from adult healthy donors. Functional recov-ery was assessed by Basso–Beattie–Bresnahan (BBB) score weekly for 28 days. Our resultsshowed gradual improvement of locomotor function in transplanted rats with statisticallysignificant differences at 21 and 28 days. Immunocytochemical analysis using human nuclei(NUMA) and BrdU antibodies confirmed survival and migration of hMSCs into the injurysite. Transplanted cells were found to infiltrate mainly into the ventrolateral white mattertracts, spreading also to adjacent segments located rostro-caudaly to the injury epicenter.In double-stained preparations, hMSCs were found to differentiate into oligodendrocytes(APC), but not into cells expressing neuronal markers (NeuN). Accumulation of GAP-43regrowing axons within damaged white matter tracts after transplantation was observed.Our findings indicate that hMSCs may facilitate recovery from spinal cord injury by re-myelinating spared white matter tracts and/or by enhancing axonal growth. In addition,low immunogenicity of hMSCs was confirmed by survival of donor cells without immuno-suppressive treatment.KEY WORDS: mesenchymal stem cells; spinal cord trauma; cell therapy; regeneration.INTRODUCTIONThe experimental studies dealing with adult bone marrow (BM) derived mes-enchymal stem/progenitor cells (MSCs) isolation, propagation, and differentiationhave been considered very important and intriguing after having shown that these1Institute of Neurobiology, Center of Excellence, SAS,ˇSoltésovej 4, Koˇ sice 04001, Slovakia.2Associated Tissue Bank, Faculty of Medicine and University Hospital, P.J.ˇSafárik University, TriedaSNP 1, Koˇ sice 04011, Slovakia.3UVM, Komenského 72, Koˇ sice, Slovakia.4To whom correspondence should be addressed at Institute of Neurobiology, Center of Excellence,SAS,ˇSoltésovej 4, Koˇ sice 04001, Slovakia; e-mail: cizkova@saske.sk.11670272-4340/06/1100-1167/1 C ?2006 Springer Science+Business Media, Inc.

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