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    188宝金博页面版: Parathyroid hormone treatment improves the cortical bone micro-structure by improving the distribution of type I collagen in pos

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    内容提示： Parathyroid hormone treatment improves the cortical bonemicro-structure by improving the distribution of type I collagenin postmenopausal women with osteoporosisMaria-Grazia Ascenzi 1 , Vivian P. Liao 1 , Brittany M. Lee 1 , Fabrizio Billi 1 , Hua Zhou 2 , RobertLindsay 2,3 , Felicia Cosman 2,3 , Jeri Nieves 2,4 , John P. Bilezikian 3 , and David W. Dempster 2,5Maria-Grazia Ascenzi: mgascenzi@mednet.ucla.edu; Vivian P. Liao: vivian.p.liao@gmail.com; Brittany M. Lee:brittanylee2011@gmail.com; Fabrizio Billi...

    文档格式：PDF | 页数：21 | 浏览次数：157 | 上传日期：2016-10-12 03:04:19 | 文档星级：
    Parathyroid hormone treatment improves the cortical bonemicro-structure by improving the distribution of type I collagenin postmenopausal women with osteoporosisMaria-Grazia Ascenzi 1 , Vivian P. Liao 1 , Brittany M. Lee 1 , Fabrizio Billi 1 , Hua Zhou 2 , RobertLindsay 2,3 , Felicia Cosman 2,3 , Jeri Nieves 2,4 , John P. Bilezikian 3 , and David W. Dempster 2,5Maria-Grazia Ascenzi: mgascenzi@mednet.ucla.edu; Vivian P. Liao: vivian.p.liao@gmail.com; Brittany M. Lee:brittanylee2011@gmail.com; Fabrizio Billi: fbilli@laoh.ucla.edu; Hua Zhou: zhouh@helenhayeshosp.org; Robert Lindsay:lindsayr@helenhayeshosp.org; Felicia Cosman: cosmanf@helenhayeshosp.org; Jeri Nieves:nievesj@helenhayeshosp.org; John P. Bilezikian: JPB2@columbia.edu; David W. Dempster:dempster@helenhayeshospital.org1 UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery, University of California at LosAngeles2 Regional Bone and Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, NY3 Department of Medicine, School of Public Health, College of Physicians and Surgeons,Columbia University, New York4 Department of Division of Epidemiology, School of Public Health, College of Physicians andSurgeons, Columbia University, New York5 Department of Pathology, School of Public Health, College of Physicians and Surgeons,Columbia University, New YorkAbstractAlthough an important index, the level of bone mineral density (BMD) does not completelydescribe fracture risk. Another bone structural parameter, the orientation of type I collagen, isknown to add to risk determination, independently of BMD, ex vivo. We investigated theHaversian system of transiliac crest biopsies from postmenopausal women before and aftertreatment with parathyroid hormone (PTH). We used the birefringence of circularly polarized lightand its underlying collagen arrangements by confocal and electron microscopy, in conjunctionwith the degree of calcification by high-resolution micro-X-ray. We found that PTH treatmentincreased the Haversian system area by 48.28±38.78%; decreased bright birefringence from0.45±0.02 to 0.40±0.01 (scale zero to one, p=0.0005); increased the average percent area ofosteons with alternating birefringence from 48.15±10.27 to 66.33±7.73 (p=0.034), decreased non-Corresponding author: Maria-Grazia Ascenzi, Department of Orthopedic Surgery, University of California at Los Angeles,Rehabilitation Bldg, Room 22-69, 1000 Veteran Avenue, Los Angeles, CA 90095, Tel. 310/825-6341, Fax 310/825-5290,mgascenzi@mednet.ucla.edu.Dr. Ascenzi is the inventor under granted and pending published patent applications related to her bone micro-structural research, therights to which are licensed to Micro-Generated Algorithms, LLC, a California limited liability company in which she holds aninterest. Dr. Lindsay declares the following financial relationships: Amgen, Lilly Novartis. Dr. Cosman has obtained research supportfrom Eli Lilly and Novartis, and is a consultant, advisor and/or speaker for Eli Lilly, Merck, Novartis, Amgen and Zosano. Dr.Bilezikian is a consultant for Eli Lilly, Novartis, Amgen, Warner Chilcott, NPS Pharmaceuticals, Merck and Radius Pharmaceuticals.Dr. Dempster has obtained research support from Eli Lilly, and is a consultant and/or speaker for Eli Lilly, Merck & Co, Amgen Inc,and NPS Pharmaceuticals. All other authors have no conflicts of interest.NIH Public AccessAuthor ManuscriptJ Bone Miner Res. Author manuscript; available in PMC 2014 September 05.Published in final edited form as:J Bone Miner Res. 2012 March ; 27(3): 702–712. doi:10.1002/jbmr.1497.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript

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