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    188宝金博页面版: 2025CAP指南：头颈癌的高危HPV检测（更新版）

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    内容提示： REVIEWHead and Neck Pathology (2025) 19:115 https://doi.org/10.1007/s12105-025-01847-2oropharynx [1–3]. The distinction between HPV-indepen-dent and HPV-associated HNSCC carries signif i cant impli-cations for both clinical management and patient prognosis in specif i c anatomic subsites of the head and neck. Beyond its prognostic value, determining the HR-HPV status of a IntroductionHigh-risk human papillomavirus (HR-HPV) plays a critical role in the pathogenesis of certain head and neck squamou...

    文档格式：PDF | 页数：9 | 浏览次数：23 | 上传日期：2025-10-15 23:49:14 | 文档星级：
    REVIEWHead and Neck Pathology (2025) 19:115 https://doi.org/10.1007/s12105-025-01847-2oropharynx [1–3]. The distinction between HPV-indepen-dent and HPV-associated HNSCC carries signif i cant impli-cations for both clinical management and patient prognosis in specif i c anatomic subsites of the head and neck. Beyond its prognostic value, determining the HR-HPV status of a IntroductionHigh-risk human papillomavirus (HR-HPV) plays a critical role in the pathogenesis of certain head and neck squamous cell carcinomas (HNSCC), particularly those arising in the William C. Faquin and James S. Lewis have contributed equally as co-f i rst authors. William C. FaquinWfaquin@mgh.harvard.edu1 Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, WRN 219, Boston, MA 02114, USA2 Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA3 Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA4 Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA5 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA6 Department of Pathology and Laboratory Medicine, David Gef f en School of Medicine at UCLA, Los Angeles, CA, USA7 Of f i ce of the Director, The Joint Pathology Center, Silver Springs, MD, USA8 Department of Otolaryngology- Head and Neck Surgery, Ohio State University Wexner Medical Center, Columbus, OH, USA9 Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA10 Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USAAbstractHigh-risk human papillomavirus (HPV) plays a signif i cant role in the pathogenesis of certain head and neck (HN) can-cers, especially squamous cell carcinomas (SCC) arising in the oropharynx. Distinction between HPV-independent and HPV-associated HNSCC has important implications for clinical management and patient prognosis in specif i c anatomic subsites of the head and neck. In 2018, the College of American Pathologists (CAP) issued 14 evidence-based guideline statements related to the testing, application, interpretation, and reporting of HPV and surrogate marker testing for HN carcinomas. Since that time, signif i cant amounts of new data have been published which serves as the foundation for the updated 2025 CAP Guideline resulting in 16 evidence-based recommendations. These statements ref i ne issues related to the application of high-risk HPV testing in patients with HNSCC, and they address some issues not fully covered in the 2018 CAP Guideline. This brief review discusses the changes that were made to the original guideline and provides a quick reference for the testing recommendations across head and neck sites.Keywords HPV · Head and neck · Squamous cell carcinoma · Testing · Oropharynx · RNA ISH · Sinonasal carcinoma · p16Received: 14 August 2025 / Accepted: 6 September 2025© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025High-Risk HPV Testing in Head and Neck Carcinoma: Key Updates from the 2025 College of American Pathologists GuidelineWilliam C. Faquin 1  · James S. Lewis Jr. 2  · Beth Beadle 3  · Justin A. Bishop 4  · Rebecca D. Chernock 5  · Jef f rey F. Krane 6  · Joel T. Moncur 7  · James W. Rocco 8  · Mary R. Schwartz 9  · Raja R. Seethala 101 3

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