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STUDY PROTOCOL Open AccessYouth Early-intervention Study (YES) –group interventions targeting socialparticipation and physical well-being as anadjunct to treatment as usual: studyprotocol for a randomized controlled trialLillian Jean Gehue 1* , Elizabeth Scott 1 , Daniel Francis Hermens 1 , Jan Scott 2 and Ian Hickie 1AbstractBackground: It is increasingly acknowledged that clinical interventions for young persons with mental disordersneed to optimize social, vocational and physical functioning, and take into account developmental needs, ratherthan focusing only on the traditional target of psychiatric symptom change. However, few interventions for youthpresenting to mental health services offer a coherent rationale for multi-faceted approaches that efficiently addressall these targets.This trial uses two facilitated group therapy modules (social and physical activity) as a vehicle for promoting clinical,cognitive, social and vocational change. The modules are an adjunct to usual treatments offered to youth attendingmental health services in Sydney, Australia.Methods/Design: The design is a 2-arm, parallel group cross-over, randomized clinical trial (RCT) that examines theefficacy of this adjunctive youth early intervention program (called “YES”) for improving social, vocational, mentaland physical health functioning in a trans-diagnostic sample of 120 young persons aged 14–25 years who arecurrently receiving a range of “usual treatments” for clinically diagnosed anxiety, affective and/or psychotic disorders.Individuals who provide written informed consent are offered 2 group therapy modules (each comprising 4 hours perweek for 8 weeks) with a 3-week “pause” between modules. Randomization determines whether individualscommence with module A or module B. The sample will be assessed pre-randomization, and at week 1 and week8 (after completion of the first module), and at week 11 (commencement of second module) and week 19(completion of second module). Final follow–up is 1-year post trial entry.Discussion: If the findings of this exploratory trial demonstrate benefits in the target domains, then it will beimportant to extend the research by undertaking: (a) a comparison of the YES program to a control interventionin a randomized controlled trial, (b) an explanatory study of putative mediators of change, and (c) a multi-centertrial with a number of trained therapists offering the group modules combined with a longer follow-up period.Trial registration: Australian New Zealand Controlled Trial Registration: ACTRN1262400175673, Date: 16 July 2015Keywords: Youth, Adolescents, Mental disorders, Physical health, Psychological intervention, Exercise, Functioning,Randomized, Cross-over* Correspondence: gehue@icloud.com1 Clinical Research Unit, Brain and Mind Research Institute, The University ofSydney, Sydney, NSW, AustraliaFull list of author information is available at the end of the articleTRIALS© 2015 Gehue et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Gehue et al. Trials (2015) 16:333 DOI 10.1186/s13063-015-0834-7