188宝金博页面版

  • 图案背景
  • 纯色背景
视图
标记
批注
批注本地保存成功，开通会员云端永久保存 去开通
a336661130

上传于：2015-12-22

粉丝量：24

从大学毕业后一直做酒店管理，在管理方面认识还不错！


  • 相关
  • 目录
  • 笔记
  • 书签

188宝金博页面版:更多相关文档

  • Comparison of radiation regimens in the treatment of Glioblastoma multiforme： results from a single institution

    星级： 9 页

  • Comparison of radiation regimens in the treatment of Glioblastoma multiforme results from a single institution

    星级： 12 页

  • 'The Single Audit - from the point of view of the

    星级： 5 页

  • the i n h a b i t a n t s of mars

    星级： 5 页

  • The role of brachytherapy in the treatment of glioblastoma multiforme

    星级： 17 页

  • Results of Part I

    星级： 2 页

  • A Single Copy of

    星级： 8 页

  • synthesis of results from the

    星级： 37 页

  • The results of surgery in the treatment of toxic goitre a review of 172 cases

    星级： 6 页

  • A survey of other results

    星级： 17 页

  • I am from a long line of survivors,

    星级： 2 页

  • From treatment planning to treatment results The luck of the draw

    星级： 2 页

  • k i n d of pol i t i c a l

    星级： 4 页

  • comparison of the functional results of single lung

    星级： 9 页

  • Phase II study of Thalidomide in the treatment of recurrent glioblastoma multiforme

    星级： 8 页

暂无目录

点击鼠标右键菜单,创建目录

    暂无笔记

    选择文本，点击鼠标右键菜单，添加笔记

    暂无书签

    在左侧文档中，点击鼠标右键，添加书签

    188宝金博页面版: Comparison of radiation regimens in the treatment of Glioblastoma multiforme results from a single institution

    下载积分： 3000

    内容提示： RESEARCH Open AccessComparison of radiation regimens in the treatmentof Glioblastoma multiforme: results from asingle institutionMelissa Azoulay 1 , Fabiano Santos 2 , Luis Souhami 1 , Valerie Panet-Raymond 1 , Kevin Petrecca 3 , Scott Owen 4 ,Marie-Christine Guiot 5 , Mariia Patyka 6 , Siham Sabri 1,6 , George Shenouda 1 and Bassam Abdulkarim 1*AbstractBackground: The optimal fractionation schedule of radiotherapy (RT) for Glioblastoma multiforme (GBM) is yet tobe determined. We aim to compare different f...

    文档格式：PDF | 页数：9 | 浏览次数：480 | 上传日期：2015-12-22 10:01:22 | 文档星级：
    RESEARCH Open AccessComparison of radiation regimens in the treatmentof Glioblastoma multiforme: results from asingle institutionMelissa Azoulay 1 , Fabiano Santos 2 , Luis Souhami 1 , Valerie Panet-Raymond 1 , Kevin Petrecca 3 , Scott Owen 4 ,Marie-Christine Guiot 5 , Mariia Patyka 6 , Siham Sabri 1,6 , George Shenouda 1 and Bassam Abdulkarim 1*AbstractBackground: The optimal fractionation schedule of radiotherapy (RT) for Glioblastoma multiforme (GBM) is yet tobe determined. We aim to compare different fractionation regimens and identify prognostic factors to better tailorRT for newly diagnosed GBM patients.Methods: All data for patients who underwent surgery for GBM between January 2005 and December 2012 werecompiled. Clinical information was collected using patient charts and government registry. Cox analysis was used toidentify variables affecting survival and treatment outcome.Results: The median follow-up time was 13.2 months. Two hundred and seventy-six patients met the inclusioncriteria, including 147 patients in the 60 Gy in 30 fractions (ConvRT) group, 86 patients in the 60 Gy in 20 fractions(HF60) group, and 43 patients in the 40 Gy in 15 fractions (HF40) group. Median survival (MS) was 16.0 months witha median progression-free survival (PFS) of 9.23 months in the ConvRT group. This was comparable to outcome inthe HF60 group with MS 15.0 months and a median PFS of 9.1 months. Patients in the HF40 group had MS of8 months, with a median PFS 5.4 months. Cox analysis showed no significant difference in OS between the ConvRTand HF60 groups but worse outcome in the HF40 group (HR 2.22, P = 0.04). MGMT methylation, extent of resection,use of chemotherapy, and repeat surgery were found to be significant independent prognostic factors for survival.Conclusions: HF60 constitutes a safe RT approach that shows survival comparable to standard RT while allowingfor a shorter treatment time.Keywords: Glioblastoma, Radiation, Hypofractionation, Temozolomide, MGMTIntroductionGlioblastoma multiforme (GBM) is the most lethal formof primary brain tumor in adults. Maximal safe resec-tion followed by radiotherapy (RT) with concomitantand adjuvant temozolomide (TMZ) is the current stan-dard of care [1,2]. O6-methylguanine-DNA methyltrans-ferase (MGMT) is a DNA-repair protein that protectsGBM tumor cells against alkylating agents by removingalkyl adducts from the O6-position of guanine [3].MGMT promoter methylation has been accepted as asignificant prognostic biomarker, with a median survivalof 23.4 months for GBM patients with methylatedMGMT, compared to 12.6 months in the case ofunmethylated tumors [4].The current standard RT regimen for GBM involves thedelivery of 60 Gy in 2.0 Gy per fraction, delivered over6 weeks. Hypofractionation refers to the use of a fewernumber of larger sized fractions to reduce the overalltreatment time, limit tumor repopulation, and potentiallyincrease cell kill [5,6]. At this time, hypofractionation hasbeen administered mostly to patients over 65 years of ageand/or with poor performance status, patients who mightderive only limited benefit from combined chemoradiation* Correspondence: bassam.abdulkarim@mcgill.ca1 Department of Oncology, Division of Radiation Oncology, McGill University,Montreal General Hospital, 1650 Avenue Cedar, H3G 1A4 Montréal, QC,CanadaFull list of author information is available at the end of the article© 2015 Azoulay et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the CreativeCommons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work is properly credited. The Creative Commons Public DomainDedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,unless otherwise stated.Azoulay et al. Radiation Oncology (2015) 10:106 DOI 10.1186/s13014-015-0396-6

    阅读了该文档的用户还阅读了这些文档

    188宝金博页面版:关于我们

    188宝金博页面版:帮助中心

    188宝金博页面版:关注我们

    • 新浪微博

    关注188宝金博页面版公众号

    188宝金博页面版
    阅读
    APP
    阅读
    返回
    顶部
    188宝金博页面版官网登录在线平台入口（2026已更新）—江苏协昌电子科技股份有限公司