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    188宝金博页面版: Vitamin D and remyelination in multiple sclerosis

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    内容提示： Neurología. 2018;33(3):177—186NEUROLOG?Awww.elsevier.es/neurologiaREVIEW ARTICLEVitamin D and remyelination in multiple sclerosis ?J. Matías-Guíu ? , C. Oreja-Guevara, J.A. Matias-Guiu, U. Gomez-PinedoServicio de Neurología, Hospital Clinico San Carlos, Facultad de Medicina, Universidad Complutense, IdiSSC, Madrid, SpainReceived 8 May 2016; accepted 12 May 2016Available online 26 February 2018KEYWORDSMyelin;Vitamin D;Vitamin D receptor;Oligodendrocyte;Oligode...

    文档格式：PDF | 页数：10 | 浏览次数：4 | 上传日期：2022-05-14 14:08:32 | 文档星级：
    Neurología. 2018;33(3):177—186NEUROLOGÍAwww.elsevier.es/neurologiaREVIEW ARTICLEVitamin D and remyelination in multiple sclerosis ?J. Matías-Guíu ∗ , C. Oreja-Guevara, J.A. Matias-Guiu, U. Gomez-PinedoServicio de Neurología, Hospital Clinico San Carlos, Facultad de Medicina, Universidad Complutense, IdiSSC, Madrid, SpainReceived 8 May 2016; accepted 12 May 2016Available online 26 February 2018KEYWORDSMyelin;Vitamin D;Vitamin D receptor;Oligodendrocyte;Oligodendrocyteprogenitor cells;Multiple sclerosisAbstractIntroduction: Several studies have found an association between multiple sclerosis and vitaminD (VD) def i ciency, which suggests that VD may play a role in the immune response. However,few studies have addressed its role in remyelination.Development: The VD receptor and the enzymes transforming VD into metabolites which acti-vate the VD receptor are expressed in central nervous system (CNS) cells, which suggests apotential effect of VD on the CNS. Both in vitro and animal model studies have shown thatVD may play a role in myelination by acting on factors that inf l uence the microenvironmentwhich promotes both proliferation and differentiation of neural stem cells into oligodendro-cyte progenitor cells and oligodendrocytes. It remains unknown whether the mechanisms ofinternalisation of VD in the CNS are synergistic with or antagonistic to the mechanisms thatfacilitate the entry of VD metabolites into immune cells.Conclusions: VD seems to play a role in the CNS and our hypothesis is that VD is involved inremyelination. Understanding the basic mechanisms of VD in myelination is necessary to managemultiple sclerosis patients with VD def i ciency.© 2016 Sociedad Espa˜ nola de Neurolog´?a. Published by Elsevier Espa˜ na, S.L.U. This is an openaccess article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).?Please cite this article as: Matías-Guíu J, Oreja-Guevara C, Matias-Guiu JA, Gomez-Pinedo U. Vitamina D y remielinización en laesclerosis múltiple. Neurología. 2018;33:177—186.∗Corresponding author.E-mail address: matiasguiu@gmail.com (J. Matías-Guíu).2173-5808/© 2016 Sociedad Espa˜ nola de Neurolog´?a. Published by Elsevier Espa˜ na, S.L.U. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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