269 Zeki OGURTAN 1 Fatih HATIPOGLU 2 Cengiz CEYLAN 3 1 University of Selcuk, Department of Surgery Konya-TÜRK?YE 2 University of Selcuk, Department of Pathology Konya-TÜRK?YE 3 University of Selcuk, Department of Surgery, Konya-TÜRK?YE Geli? Tarihi : 13.11.2007 Kabul Tarihi : 29.11.2007 Comparative Evaluation of Demineralized and Mineralized Xenogeneic Bovine Bone Powder and Chips on the Healing of Circumscribed Radial Bone Defects in the Dog Healing of circumscribed defects made in the radius of dogs were evaluated using demineralized and mineralized xenogeneic bovine bone powder and chips at 2, 4, 6, 8, 12 weeks. No foreign body reactions and postoperative complications were encountered. Presence of more bone formation in the defects filled with demineralized xenogeneic bovine bone powder compared to other graft-filled defects explains the importance of demineralization process and smallness of the graft size. Comparison of the appearance of bone healing and formation pattern in demineralized and mineralized xenogeneic bovine bone powder and chips shows the remarkable histologic difference of field phenomenon bone formation in favour of demineralized bone powder. Based on these findings, demineralized xenogeneic bovine bone powder being not species specific may be a good implant with respect to availability of wide variety of animal resources as animal donor, easy preparation and storage in advance. Key Words: Circumscribed defect, Xenogeneic implant, Demineralized powder and chip, Mineralized powder and chip, Dog. Köpeklerde Xenogenik Demineralize ve Mineralize Kemik Tozu ve Partiküllerinin Dairesel Kemik Defeklerinin ?yile?mesi Üzerindeki Etkilerinin Kar??la?t?rmal? Olarak De?erlendirilmesi Köpeklerin radiusunda yap?lan dairesel defeklerde demineralize ve mineralize xenogenik s???r tozu ve partiküllerinin 2, 4, 6, 8 ve 12. haftalardaki iyile?me seyirleri kar??la?t?rmal? olarak de?erlendirildi. Yabanc? cisim reaksiyonu ve herhangi bir postoperatif yan etkiye rastlanmad?. Demineralize s???r xenogenik kemik tozu ile doldurulan defeklerin di?er formlardaki graf ile doldurulan defek iyile?melerine göre daha fazla kemik dokusu olu?turmas? demineralizasyon ile birlikte graf ölçü küçüklü?ünün önemini ortaya koymaktad?r. Demineralize ve mineralize xenogenik kemik tozu ile partiküllerinin kemik iyile?mesi ve olu?um özelliklerinin kar??la?t?r?lmas? demineralize kemik tozu lehine aç?k bir ?ekilde alan fenomeni farkl?l???n? göstermektedir. Bu bulgulara dayanarak, türe özgü olmayan demineralize xenogenik s???r kemik tozunun verici olarak çok geni? hayvan kaynaklar?n?n bulunmas?, kolay uygulanmas?, haz?rlanmas? ve depolanabilme özelli?i iyi bir graf materyali oldu?unu ifade etmektedir. Anahtar Kelimeler: Dairesel defek, Xenogenik graf, Demineralize toz ve partikül, Mineralize toz ve partikül, Köpek. Introduction Autogeneneic and allogeneic bone grafts have been widely used for stimulation of fracture healing (1), delayed and nonunion of fractures, infected and contaminated fractures, filling of defects formed after osteomyelitis, following removal of bone neoplasms, arthrodesis, and large segmental defects (1, 2), and prevention of refracture of long bones after plate removal as a result of stress shielding effect of a plate (3). Prolongation of anesthesia and surgery, risk of infection, limited quantities for harvest, structural defects at the donor site along with severe postoperative pain have been encountered with autogeneic bone grafting (4, 5). It is generally in agreement that fresh autogeneic grafts are superior to fresh or stored allogeneic and xenogeneic grafts (6-9) but, the delay in the incorporation of allogeneic bone graft as compared to that of auogeneic bone graft has not caused to hamper its clinical use. ARA?TIRMA 2007: 21 (6): 269 - 276 http://www.fusabil.org Yaz??ma Adresi Correspondence Zeki OGURTAN University of Selcuk, Department of Surgery Konya -TÜRK?YE zogurtan@selcuk.edu.t
