wcjd@wjgnet.com 世界华人消化杂志 2009年9月8日; 17(25): 2625-2630ISSN 1009-3079 CN 14-1260/R 临床经验 CLINICAL PRACTICE血清胃蛋白酶原Ⅰ、Ⅱ和G-17在功能性消化不良患者中的表达及其意义刘 露, 姜 敏刘露, 姜敏, 中国医科大学附属第一医院消化内科 辽宁省沈阳市 110001作者贡献分布: 课题设计、文献检索、资料分析及论文撰写由刘露完成; 选题与审校由姜敏完成.通讯作者: 姜敏, 教授, 110001, 辽宁省沈阳市, 中国医科大学附属第一医院消化内科. jiang- min@163.com电话: 024- 83282199收稿日期: 2009- 06- 20 修回日期: 2009- 08- 24接受日期: 2009- 08- 31 在线出版日期: 2009- 09- 08Clinical significance of serum pepsinogen I and II and gastrin-17 in patients with functional dyspepsia Lu Liu, Min JiangLu Liu, Min Jiang, Department of Gastroenterology, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, ChinaCorrespondence to: Professor Min Jiang, Department of Gastroenterology, the First Hospital of China Medical Uni-versity, Shenyang 110001, Liaoning Province, China. jiang-min@163.comReceived: 2009-06-20 Revised: 2009-08-24Accepted: 2009-08-31 Published online: 2009-09-08 AbstractAIM: To investigate the clinical significance of serum pepsinogen (PG) I and II and gastrin-17 (G-17) in patients with functional dyspepsia (FD).METHODS: A case-control study was per-formed. Two hundreds and twenty-nine FD patients recruited were diagnosed according to Rome III criteria. Serum PG I and II and G-17 levels were measured by enzyme-linked immu-nosorbent assay (ELISA). The PG I/II ratio (PGR) was calculated. Serum IgG antibody against Helicobacter pylori (H pylori) was determined by ELISA to evaluate H pylori infection. RESULTS: In FD patients, the PGR was lower in the ≥ 61 age group than in the ≤ 40 age group (P = 0.049). The levels of serum PG II and G-17 were significantly higher in FD patients than in normal controls (both P = 0.000), while the PGR was significantly lower in FD patients than in normal controls (P = 0.000). No significant dif-ference was noted in serum PG I level between FD patients and normal controls (P = 0.067). The receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off points of PG II and G-17 values for the diagnosis of FD were 13.2 μg/L (sensitivity 52.8%, specificity 100%, and accuracy 67.5%) and 6.84 μg/L (sen-sitivity 52.8%, specificity 100%, and accuracy 67.5%), respectively. The levels of serum PG I and PG II were significantly higher in male FD patients than in female ones (P = 0.003 and 0.004, respectively). The positive rate of serum IgG an-tibody against H pylori was higher in FD patients than in normal controls (P = 0.028). CONCLUSION: The levels of serum PGII and G-17 are elevated in FD patients, which may suggest functional changes in gastric sinus and proximal duodenal mucosa. There is an associa-tion between FD and H pylori infection. Key Words: Functional dyspepsia; Pepsinogen; Gastrin-17; Helicobacter pyloriLiu L, Jiang M. Clinical significance of serum pepsinogen I and II and gastrin-17 in patients with functional dyspepsia. Shijie Huaren Xiaohua Zazhi 2009; 17(25): 2625-2630摘要目的: 探讨功能性消化不良(FD)患者血清胃蛋白酶原(PG)Ⅰ、Ⅱ及胃泌素-17(G-17)的水平和意义.方法: 根据罗马Ⅲ诊断标准, 229例FD患者纳入本研究. 均采用酶联免疫吸附试验(ELISA)定量测定血清PGⅠ、PGⅡ和G-17含量, 计算PGⅠ/Ⅱ比值(PGR), 血清幽门螺杆菌(H pylori)抗体滴度大于等于35EIU为阳性. 结果: 以≤40岁、41-50岁、51-60岁和≥61岁进行年龄分组. FD组年龄≥61岁组PGR低于≤40岁组(P = 0.049). FD患者PGⅡ、G-17水平要明显高于对照组(P = 0.000, 0.000), PGⅠwww.wjgnet.com®■ 背景资料近年来研究发现大多数胃肠疾病均存在PG与G-17改变, 但在FD患者中PG与G-17是否存在改变尚未引起关注.■ 同行评议者季国忠, 教授, 南京医科大学第二附属医院消化科
